TY  - GEN
AU  - Xu,Shilin
AU  - Aguilar,Angelo
AU  - Xu,Tianfeng
AU  - Zheng,Ke
AU  - Huang,Liyue
AU  - Stuckey,Jeanne
AU  - Chinnaswamy,Krishnapriya
AU  - Bernard,Denzil
AU  - Fernández-Salas,Ester
AU  - Liu,Liu
AU  - Wang,Mi
AU  - McEachern,Donna
AU  - Przybranowski,Sally
AU  - Foster,Caroline
AU  - Wang,Shaomeng
TI  - Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction
SN  - 1521-3773
PY  - 2019///0403
KW  - Antineoplastic Agents
KW  - chemistry
KW  - Binding Sites
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - drug effects
KW  - Crystallography, X-Ray
KW  - Drug Design
KW  - Histone-Lysine N-Methyltransferase
KW  - antagonists & inhibitors
KW  - Humans
KW  - Molecular Dynamics Simulation
KW  - Myeloid-Lymphoid Leukemia Protein
KW  - Protein Interaction Domains and Motifs
KW  - Protein Structure, Tertiary
KW  - Proto-Oncogene Proteins
KW  - Small Molecule Libraries
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S
UR  - https://doi.org/10.1002/anie.201711828
ER  -