TY  - GEN
AU  - Gregory,Michael C
AU  - Mak,Piotr J
AU  - Khatri,Yogan
AU  - Kincaid,James R
AU  - Sligar,Stephen G
TI  - Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202
SN  - 1520-4995
PY  - 2018///0529
KW  - 17-alpha-Hydroxypregnenolone
KW  - metabolism
KW  - 17-alpha-Hydroxyprogesterone
KW  - Amino Acid Sequence
KW  - Amino Acid Substitution
KW  - Androstenedione
KW  - biosynthesis
KW  - Animals
KW  - Catalysis
KW  - Catalytic Domain
KW  - Conserved Sequence
KW  - Dehydroepiandrosterone
KW  - Genes, Synthetic
KW  - Humans
KW  - Hydrogen Bonding
KW  - Mammals
KW  - genetics
KW  - Models, Molecular
KW  - Mutation, Missense
KW  - Point Mutation
KW  - Protein Binding
KW  - Protein Conformation
KW  - Recombinant Proteins
KW  - Sequence Alignment
KW  - Sequence Homology, Amino Acid
KW  - Steroid 17-alpha-Hydroxylase
KW  - chemistry
KW  - Substrate Specificity
N1  - Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
UR  - https://doi.org/10.1021/acs.biochem.7b01067
ER  -