First-in-Class ERK1/2 Inhibitor Ulixertinib (BVD-523) in Patients with MAPK Mutant Advanced Solid Tumors: Results of a Phase I Dose-Escalation and Expansion Study. [electronic resource]
- Cancer discovery 02 2018
- 184-195 p. digital
Adult Aged Aged, 80 and over Aminopyridines--pharmacology Female Humans Magnetic Resonance Imaging Male Middle Aged Mitogen-Activated Protein Kinase 1--antagonists & inhibitors Mitogen-Activated Protein Kinase 3--antagonists & inhibitors Mitogen-Activated Protein Kinases--genetics Mutation Neoplasm Staging Neoplasms--diagnosis Protein Kinase Inhibitors--pharmacology Pyrroles--pharmacology Tomography, X-Ray Computed Treatment Outcome Young Adult