Lagares, David
Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis. [electronic resource]
- Science translational medicine Dec 2017
Publication Type: Journal Article
ISSN: 1946-6242
Standard No.: 10.1126/scitranslmed.aal3765 doi
Subjects--Topical Terms: Aniline Compounds--pharmacology Animals Apoptosis--drug effects Biomechanical Phenomena Cell Survival--drug effects Dermis--pathology Disease Models, Animal Extracellular Matrix--metabolism Fibrosis Humans Male Mechanotransduction, Cellular--drug effects Mice, Inbred C57BL Mitochondria--drug effects Mitochondrial Membranes--drug effects Myofibroblasts--drug effects Scleroderma, Systemic--pathology Signal Transduction--drug effects Sulfonamides--pharmacology bcl-X Protein--metabolism