TY  - GEN
AU  - Košak,Urban
AU  - Brus,Boris
AU  - Knez,Damijan
AU  - Žakelj,Simon
AU  - Trontelj,Jurij
AU  - Pišlar,Anja
AU  - Šink,Roman
AU  - Jukič,Marko
AU  - Živin,Marko
AU  - Podkowa,Adrian
AU  - Nachon,Florian
AU  - Brazzolotto,Xavier
AU  - Stojan,Jure
AU  - Kos,Janko
AU  - Coquelle,Nicolas
AU  - Sałat,Kinga
AU  - Colletier,Jacques-Philippe
AU  - Gobec,Stanislav
TI  - The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity
SN  - 1520-4804
PY  - 2019///0225
KW  - Animals
KW  - Butyrylcholinesterase
KW  - chemistry
KW  - Cholinesterase Inhibitors
KW  - Crystallography, X-Ray
KW  - Drug Design
KW  - Female
KW  - Humans
KW  - Kinetics
KW  - Male
KW  - Mice
KW  - Models, Molecular
KW  - Protein Binding
KW  - Protein Conformation
KW  - Rats
KW  - Safety
KW  - Thermodynamics
KW  - Tissue Distribution
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1021/acs.jmedchem.7b01086
ER  -