Košak, Urban <br/><br/>
The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity.  [electronic resource] 

 -  Journal of medicinal chemistry  01 2018 
 - 119-139 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/acs.jmedchem.7b01086  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Butyrylcholinesterase--chemistry<br/>Cholinesterase Inhibitors--chemistry<br/>Crystallography, X-Ray<br/>Drug Design<br/>Female<br/>Humans<br/>Kinetics<br/>Male<br/>Mice<br/>Models, Molecular<br/>Protein Binding<br/>Protein Conformation<br/>Rats<br/>Safety<br/>Thermodynamics<br/>Tissue Distribution