Targeting PI3K, mTOR, ERK, and Bcl-2 signaling network shows superior antileukemic activity against AML ex vivo. [electronic resource]
- Biochemical pharmacology 02 2018
- 13-26 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1873-2968
10.1016/j.bcp.2017.11.022 doi
Adolescent Adult Aged Antineoplastic Agents--pharmacology Cell Line, Tumor Cell Survival--drug effects Child Child, Preschool Drug Delivery Systems Extracellular Signal-Regulated MAP Kinases--genetics Female Gene Expression Regulation--drug effects Humans Leukemia, Myeloid, Acute--drug therapy Male Metabolic Networks and Pathways--drug effects Middle Aged Phosphatidylinositol 3-Kinases--genetics Proto-Oncogene Proteins c-bcl-2--genetics TOR Serine-Threonine Kinases--genetics Up-Regulation Young Adult