TY  - GEN
AU  - Takata,Kazuyuki
AU  - Amamiya,Takahide
AU  - Mizoguchi,Hiroaki
AU  - Kawanishi,Shohei
AU  - Kuroda,Eriko
AU  - Kitamura,Risa
AU  - Ito,Aina
AU  - Saito,Yuki
AU  - Tawa,Manami
AU  - Nagasawa,Tomofumi
AU  - Okamoto,Haruka
AU  - Sugino,Yuko
AU  - Takegami,Shigehiko
AU  - Kitade,Tatsuya
AU  - Toda,Yuki
AU  - Kem,William R
AU  - Kitamura,Yoshihisa
AU  - Shimohama,Shun
AU  - Ashihara,Eishi
TI  - Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer's disease
SN  - 1558-1497
PY  - 2018///0926
KW  - Alzheimer Disease
KW  - complications
KW  - Amyloid Precursor Protein Secretases
KW  - metabolism
KW  - Amyloid beta-Peptides
KW  - immunology
KW  - Animals
KW  - Benzylidene Compounds
KW  - pharmacology
KW  - Brain
KW  - Cells, Cultured
KW  - Cognitive Dysfunction
KW  - drug therapy
KW  - Disease Models, Animal
KW  - Humans
KW  - Mice, Transgenic
KW  - Microglia
KW  - Neuroblastoma
KW  - Phagocytosis
KW  - drug effects
KW  - Pyridines
KW  - Rats
KW  - Tumor Cells, Cultured
KW  - alpha7 Nicotinic Acetylcholine Receptor
KW  - agonists
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.neurobiolaging.2017.10.021
ER  -