Takata, Kazuyuki <br/><br/>
Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer's disease.  [electronic resource] 

 -  Neurobiology of aging  02 2018 
 - 197-209 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1558-1497 
<br/><br/><label>Standard No.: </label>10.1016/j.neurobiolaging.2017.10.021  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Alzheimer Disease--complications<br/>Amyloid Precursor Protein Secretases--metabolism<br/>Amyloid beta-Peptides--immunology<br/>Animals<br/>Benzylidene Compounds--pharmacology<br/>Brain--metabolism<br/>Cells, Cultured<br/>Cognitive Dysfunction--drug therapy<br/>Disease Models, Animal<br/>Humans<br/>Mice, Transgenic<br/>Microglia--immunology<br/>Neuroblastoma--metabolism<br/>Phagocytosis--drug effects<br/>Pyridines--pharmacology<br/>Rats<br/>Tumor Cells, Cultured<br/>alpha7 Nicotinic Acetylcholine Receptor--agonists