TY  - GEN
AU  - Fu,Chengzhang
AU  - Sikandar,Asfandyar
AU  - Donner,Jannik
AU  - Zaburannyi,Nestor
AU  - Herrmann,Jennifer
AU  - Reck,Michael
AU  - Wagner-Döbler,Irene
AU  - Koehnke,Jesko
AU  - Müller,Rolf
TI  - The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD
SN  - 2041-1723
PY  - 2018///0907
KW  - Aminohydrolases
KW  - metabolism
KW  - Anti-Bacterial Agents
KW  - pharmacology
KW  - Antineoplastic Agents
KW  - Bacterial Proteins
KW  - Biofilms
KW  - drug effects
KW  - Biological Products
KW  - Cell Line, Tumor
KW  - Crystallography, X-Ray
KW  - Enzyme Assays
KW  - Folic Acid
KW  - Formate-Tetrahydrofolate Ligase
KW  - Humans
KW  - Inhibitory Concentration 50
KW  - Macrolides
KW  - Methylenetetrahydrofolate Dehydrogenase (NADP)
KW  - Microbial Sensitivity Tests
KW  - Minor Histocompatibility Antigens
KW  - Mitochondria
KW  - Multienzyme Complexes
KW  - Multifunctional Enzymes
KW  - Myxococcales
KW  - Neoplasms
KW  - drug therapy
KW  - Protein Binding
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/s41467-017-01671-5
ER  -