Fingolimod reduces neuropathic pain behaviors in a mouse model of multiple sclerosis by a sphingosine-1 phosphate receptor 1-dependent inhibition of central sensitization in the dorsal horn. [electronic resource]
- Pain 02 2018
- 224-238 p. digital
Publication Type: Journal Article
1872-6623
10.1097/j.pain.0000000000001106 doi
Anilides--pharmacology Animals Central Nervous System Sensitization--drug effects Disease Models, Animal Female Fingolimod Hydrochloride--therapeutic use Immunosuppressive Agents--therapeutic use Male Mice Mice, Inbred C57BL Motor Activity--drug effects Multiple Sclerosis--chemically induced Myelin-Oligodendrocyte Glycoprotein--toxicity Neuralgia--drug therapy Organophosphonates--pharmacology Oxadiazoles--pharmacology Pain Threshold--drug effects Peptide Fragments--toxicity Receptors, Lysosphingolipid--metabolism Sphingosine-1-Phosphate Receptors Spinal Cord--metabolism Spinal Nerve Roots--drug effects Subcellular Fractions--drug effects Thiophenes--pharmacology eIF-2 Kinase--metabolism