TY - GEN AU - Sivaramakrishnan,Manaswini AU - McCarthy,Kathleen D AU - Campagne,Sébastien AU - Huber,Sylwia AU - Meier,Sonja AU - Augustin,Angélique AU - Heckel,Tobias AU - Meistermann,Hélène AU - Hug,Melanie N AU - Birrer,Pascale AU - Moursy,Ahmed AU - Khawaja,Sarah AU - Schmucki,Roland AU - Berntenis,Nikos AU - Giroud,Nicolas AU - Golling,Sabrina AU - Tzouros,Manuel AU - Banfai,Balazs AU - Duran-Pacheco,Gonzalo AU - Lamerz,Jens AU - Hsiu Liu,Ying AU - Luebbers,Thomas AU - Ratni,Hasane AU - Ebeling,Martin AU - Cléry,Antoine AU - Paushkin,Sergey AU - Krainer,Adrian R AU - Allain,Frédéric H-T AU - Metzger,Friedrich TI - Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers SN - 2041-1723 PY - 2018///0907 KW - Biflavonoids KW - pharmacology KW - Cell-Free System KW - Computational Biology KW - Epoxy Compounds KW - Exons KW - genetics KW - Fibroblasts KW - HEK293 Cells KW - HeLa Cells KW - Humans KW - Ligands KW - Macrolides KW - Muscular Atrophy, Spinal KW - drug therapy KW - Piperazines KW - chemical synthesis KW - Protein Binding KW - Protein Structure, Quaternary KW - Proteomics KW - methods KW - RNA Precursors KW - RNA Splicing KW - drug effects KW - RNA, Messenger KW - RNA-Binding Proteins KW - metabolism KW - Spliceosomes KW - Survival of Motor Neuron 1 Protein KW - Survival of Motor Neuron 2 Protein N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/s41467-017-01559-4 ER -