TY  - GEN
AU  - Rai,Ganesha
AU  - Brimacombe,Kyle R
AU  - Mott,Bryan T
AU  - Urban,Daniel J
AU  - Hu,Xin
AU  - Yang,Shyh-Ming
AU  - Lee,Tobie D
AU  - Cheff,Dorian M
AU  - Kouznetsova,Jennifer
AU  - Benavides,Gloria A
AU  - Pohida,Katie
AU  - Kuenstner,Eric J
AU  - Luci,Diane K
AU  - Lukacs,Christine M
AU  - Davies,Douglas R
AU  - Dranow,David M
AU  - Zhu,Hu
AU  - Sulikowski,Gary
AU  - Moore,William J
AU  - Stott,Gordon M
AU  - Flint,Andrew J
AU  - Hall,Matthew D
AU  - Darley-Usmar,Victor M
AU  - Neckers,Leonard M
AU  - Dang,Chi V
AU  - Waterson,Alex G
AU  - Simeonov,Anton
AU  - Jadhav,Ajit
AU  - Maloney,David J
TI  - Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)
SN  - 1520-4804
PY  - 2018///0123
KW  - Animals
KW  - Antineoplastic Agents
KW  - chemical synthesis
KW  - Cell Line, Tumor
KW  - Crystallography, X-Ray
KW  - Drug Discovery
KW  - Drug Screening Assays, Antitumor
KW  - Enzyme Inhibitors
KW  - High-Throughput Screening Assays
KW  - Humans
KW  - L-Lactate Dehydrogenase
KW  - antagonists & inhibitors
KW  - Male
KW  - Membranes, Artificial
KW  - Mice
KW  - Microsomes, Liver
KW  - drug effects
KW  - Permeability
KW  - Pyrazoles
KW  - Rats
KW  - Solubility
KW  - Structure-Activity Relationship
KW  - Thiazoles
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural
UR  - https://doi.org/10.1021/acs.jmedchem.7b00941
ER  -