Mah, Shinmee <br/><br/>
Identification of 4-Phenoxyquinoline Based Inhibitors for L1196M Mutant of Anaplastic Lymphoma Kinase by Structure-Based Design.  [electronic resource] 

 -  Journal of medicinal chemistry  11 2017 
 - 9205-9221 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/acs.jmedchem.7b01039  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Amino Acid Substitution<br/>Anaplastic Lymphoma Kinase<br/>Animals<br/>Antineoplastic Agents--administration & dosage<br/>Carbazoles--pharmacology<br/>Cell Line, Tumor<br/>Crizotinib<br/>Drug Design<br/>Drug Resistance, Neoplasm<br/>ERG1 Potassium Channel--antagonists & inhibitors<br/>Humans<br/>Kinetics<br/>Piperidines--pharmacology<br/>Pyrazoles--pharmacology<br/>Pyridines--pharmacology<br/>Pyrimidines--pharmacology<br/>Quinolines--administration & dosage<br/>Rats<br/>Receptor Protein-Tyrosine Kinases--antagonists & inhibitors<br/>Signal Transduction<br/>Structure-Activity Relationship<br/>Sulfones--pharmacology