TY  - GEN
AU  - Bueno,Ana B
AU  - Agejas,Javier
AU  - Broughton,Howard
AU  - Dally,Robert
AU  - Durham,Timothy B
AU  - Espinosa,Juan Félix
AU  - González,Rosario
AU  - Hahn,Patric J
AU  - Marcos,Alicia
AU  - Rodríguez,Ramón
AU  - Sanz,Gema
AU  - Soriano,José F
AU  - Timm,David
AU  - Vidal,Paloma
AU  - Yang,Hsiu-Chiung
AU  - McCarthy,James R
TI  - Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences
SN  - 1520-4804
PY  - 2017///1229
KW  - Amyloid Precursor Protein Secretases
KW  - antagonists & inhibitors
KW  - Animals
KW  - Aspartic Acid Endopeptidases
KW  - Brain
KW  - metabolism
KW  - Crystallography, X-Ray
KW  - Cyclization
KW  - Drug Design
KW  - Ethylamines
KW  - chemistry
KW  - Humans
KW  - Magnetic Resonance Spectroscopy
KW  - Mice
KW  - Models, Molecular
KW  - Morpholines
KW  - Peptides
KW  - Protease Inhibitors
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1021/acs.jmedchem.7b01304
ER  -