TY - GEN AU - Cook,James AU - Zusi,F Christopher AU - Hill,Matthew D AU - Fang,Haiquan AU - Pearce,Bradley AU - Park,Hyunsoo AU - Gallagher,Lizbeth AU - McDonald,Ivar M AU - Bristow,Linda AU - Macor,John E AU - Olson,Richard E TI - Design and synthesis of a novel series of (1'S,2R,4'S)-3H-4'-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2'-bicyclo[2.2.2]octanes] with high affinity for the α7 neuronal nicotinic receptor SN - 1464-3405 PY - 2017///1121 KW - Bridged Bicyclo Compounds KW - chemical synthesis KW - Crystallography, X-Ray KW - Drug Design KW - Humans KW - Hydrogen Bonding KW - Molecular Conformation KW - Nicotinic Agonists KW - chemistry KW - Octanes KW - Protein Binding KW - Receptors, Serotonin, 5-HT3 KW - Stereoisomerism KW - alpha7 Nicotinic Acetylcholine Receptor N1 - Publication Type: Journal Article UR - https://doi.org/10.1016/j.bmcl.2017.10.009 ER -