Cook, James

Design and synthesis of a novel series of (1'S,2R,4'S)-3H-4'-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2'-bicyclo[2.2.2]octanes] with high affinity for the α7 neuronal nicotinic receptor. [electronic resource] - Bioorganic & medicinal chemistry letters 11 2017 - 5002-5005 p. digital

Publication Type: Journal Article

1464-3405

10.1016/j.bmcl.2017.10.009 doi


Bridged Bicyclo Compounds--chemical synthesis
Crystallography, X-Ray
Drug Design
Humans
Hydrogen Bonding
Molecular Conformation
Nicotinic Agonists--chemistry
Octanes--chemical synthesis
Protein Binding
Receptors, Serotonin, 5-HT3--chemistry
Stereoisomerism
alpha7 Nicotinic Acetylcholine Receptor--chemistry