A mechanistic model to predict effects of cathepsin B and cystatin C on β-amyloid aggregation and degradation. [electronic resource]
- The Journal of biological chemistry 12 2017
- 21071-21082 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Validation Study
1083-351X
10.1074/jbc.M117.811448 doi
Algorithms Amino Acid Substitution Amyloid beta-Peptides--chemistry Cathepsin B--chemistry Cystatin C--chemistry Fluorescence Resonance Energy Transfer Humans Kinetics Models, Molecular Mutagenesis, Site-Directed Mutation Nerve Tissue Proteins--chemistry Osmolar Concentration Peptide Fragments--chemistry Protein Aggregation, Pathological--metabolism Protein Interaction Domains and Motifs Proteolysis Recombinant Proteins--chemistry Reproducibility of Results Solubility