Zhuge, Weishan <br/><br/>
Costunolide specifically binds and inhibits thioredoxin reductase 1 to induce apoptosis in colon cancer.  [electronic resource] 

 -  Cancer letters  01 2018 
 - 46-58 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1872-7980 
<br/><br/><label>Standard No.: </label>10.1016/j.canlet.2017.10.006  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Activating Transcription Factor 4--physiology<br/>Animals<br/>Antineoplastic Agents, Phytogenic--pharmacology<br/>Apoptosis--drug effects<br/>Colonic Neoplasms--drug therapy<br/>Endoplasmic Reticulum Stress<br/>Female<br/>HCT116 Cells<br/>Humans<br/>Mice<br/>Mice, Inbred BALB C<br/>Reactive Oxygen Species--metabolism<br/>Sesquiterpenes--metabolism<br/>Thioredoxin Reductase 1--antagonists & inhibitors<br/>Xenograft Model Antitumor Assays