TY  - GEN
AU  - Hughes,James
AU  - Dawson,Ruby
AU  - Tea,Melinda
AU  - McAninch,Dale
AU  - Piltz,Sandra
AU  - Jackson,Dominique
AU  - Stewart,Laura
AU  - Ricos,Michael G
AU  - Dibbens,Leanne M
AU  - Harvey,Natasha L
AU  - Thomas,Paul
TI  - Knockout of the epilepsy gene Depdc5 in mice causes severe embryonic dysmorphology with hyperactivity of mTORC1 signalling
SN  - 2045-2322
PY  - 2019///0626
KW  - Animals
KW  - Brain
KW  - physiopathology
KW  - CRISPR-Cas Systems
KW  - genetics
KW  - Disease Models, Animal
KW  - Epilepsy
KW  - Fibroblasts
KW  - pathology
KW  - GTPase-Activating Proteins
KW  - Gene Expression Regulation
KW  - Heterozygote
KW  - Humans
KW  - Mechanistic Target of Rapamycin Complex 1
KW  - Mice
KW  - Mice, Knockout
KW  - Multiprotein Complexes
KW  - chemistry
KW  - Mutation
KW  - Seizures
KW  - Signal Transduction
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/s41598-017-12574-2
ER  -