TY - GEN AU - Lynch,James T AU - Polanska,Urszula M AU - Delpuech,Oona AU - Hancox,Urs AU - Trinidad,Antonio G AU - Michopoulos,Filippos AU - Lenaghan,Carol AU - McEwen,Robert AU - Bradford,James AU - Polanski,Radek AU - Ellston,Rebecca AU - Avivar-Valderas,Alvaro AU - Pilling,James AU - Staniszewska,Anna AU - Cumberbatch,Marie AU - Critchlow,Susan E AU - Cruzalegui,Francisco AU - Barry,Simon T TI - Inhibiting PI3Kβ with AZD8186 Regulates Key Metabolic Pathways in PTEN-Null Tumors SN - 1557-3265 PY - 2018///0801 KW - Aniline Compounds KW - administration & dosage KW - Animals KW - Cell Line, Tumor KW - Chromones KW - Class II Phosphatidylinositol 3-Kinases KW - genetics KW - Female KW - Gene Expression Regulation, Neoplastic KW - Humans KW - Hydroxymethylglutaryl-CoA Synthase KW - Metabolic Networks and Pathways KW - Mice KW - PTEN Phosphohydrolase KW - Triple Negative Breast Neoplasms KW - drug therapy KW - Xenograft Model Antitumor Assays N1 - Publication Type: Journal Article UR - https://doi.org/10.1158/1078-0432.CCR-17-0676 ER -