Assessing molecular initiating events (MIEs), key events (KEs) and modulating factors (MFs) for styrene responses in mouse lungs using whole genome gene expression profiling following 1-day and multi-week exposures. [electronic resource]
- Toxicology and applied pharmacology 11 2017
- 28-40 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1096-0333
10.1016/j.taap.2017.09.015 doi
Animals Aryl Hydrocarbon Hydroxylases--genetics Circadian Rhythm--drug effects Circadian Rhythm Signaling Peptides and Proteins--genetics Cytochrome P-450 CYP2B6--genetics Cytochrome P-450 Enzyme System--deficiency Cytochrome P450 Family 2--genetics Dose-Response Relationship, Drug Gene Expression Profiling--methods Gene Regulatory Networks--drug effects Genotype Inhalation Exposure--adverse effects Intracellular Signaling Peptides and Proteins--genetics Lung--drug effects Male Mice, Inbred C57BL Mice, Knockout Models, Animal Phenotype Signal Transduction--drug effects Styrenes--metabolism Time Factors Toxicogenetics--methods Transcription Factors--genetics Transcriptome--drug effects