Goodwin, Justin

Targeting Hypoxia-Inducible Factor-1α/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis. [electronic resource] - American journal of respiratory cell and molecular biology 02 2018 - 216-231 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1535-4989

10.1165/rcmb.2016-0186OC doi


Animals
Bleomycin
Cell Hypoxia--physiology
Cell Line
Dichloroacetic Acid--pharmacology
Glycolysis--physiology
Humans
Hypoxia-Inducible Factor 1, alpha Subunit--genetics
Lung--pathology
Mice
Mice, Knockout
Myofibroblasts--cytology
Protein Serine-Threonine Kinases--antagonists & inhibitors
Pulmonary Fibrosis--chemically induced
Pyruvate Dehydrogenase Acetyl-Transferring Kinase
RNA Interference
RNA, Small Interfering--genetics