TY  - GEN
AU  - Bessa,Luiza M
AU  - Launay,Hélène
AU  - Dujardin,Marie
AU  - Cantrelle,François-Xavier
AU  - Lippens,Guy
AU  - Landrieu,Isabelle
AU  - Schneider,Robert
AU  - Hanoulle,Xavier
TI  - NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B
SN  - 1083-351X
PY  - 2017///1121
KW  - Allosteric Regulation
KW  - drug effects
KW  - Allosteric Site
KW  - Antiviral Agents
KW  - chemistry
KW  - Enzyme Inhibitors
KW  - Gene Deletion
KW  - Hepacivirus
KW  - enzymology
KW  - Intrinsically Disordered Proteins
KW  - Isoleucine
KW  - Models, Molecular
KW  - Mutagenesis, Site-Directed
KW  - Nuclear Magnetic Resonance, Biomolecular
KW  - Oligoribonucleotides
KW  - Peptide Fragments
KW  - antagonists & inhibitors
KW  - Point Mutation
KW  - Protein Conformation
KW  - Protein Interaction Domains and Motifs
KW  - Protein Refolding
KW  - Pyrones
KW  - RNA-Dependent RNA Polymerase
KW  - Recombinant Proteins
KW  - Solubility
KW  - Triazoles
KW  - Viral Nonstructural Proteins
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1074/jbc.M117.813766
ER  -