TY  - GEN
AU  - Einolf,Heidi J
AU  - Lin,Wen
AU  - Won,Christina S
AU  - Wang,Lai
AU  - Gu,Helen
AU  - Chun,Dung Y
AU  - He,Handan
AU  - Mangold,James B
TI  - Physiologically Based Pharmacokinetic Model Predictions of Panobinostat (LBH589) as a Victim and Perpetrator of Drug-Drug Interactions
SN  - 1521-009X
PY  - 2018///0629
KW  - Cytochrome P-450 CYP2C19
KW  - metabolism
KW  - Cytochrome P-450 CYP3A
KW  - Cytochrome P-450 Enzyme Inhibitors
KW  - pharmacology
KW  - Drug Interactions
KW  - Enzyme Induction
KW  - drug effects
KW  - Gastric Acidity Determination
KW  - Histone Deacetylase Inhibitors
KW  - adverse effects
KW  - Humans
KW  - Hydroxamic Acids
KW  - Indoles
KW  - Microsomes, Liver
KW  - enzymology
KW  - Midazolam
KW  - pharmacokinetics
KW  - Models, Biological
KW  - Oxidation-Reduction
KW  - Panobinostat
KW  - Rifampin
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1124/dmd.117.076851
ER  -