Einolf, Heidi J <br/><br/>
Physiologically Based Pharmacokinetic Model Predictions of Panobinostat (LBH589) as a Victim and Perpetrator of Drug-Drug Interactions.  [electronic resource] 

 -  Drug metabolism and disposition: the biological fate of chemicals  12 2017 
 - 1304-1316 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1521-009X 
<br/><br/><label>Standard No.: </label>10.1124/dmd.117.076851  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Cytochrome P-450 CYP2C19--metabolism<br/>Cytochrome P-450 CYP3A--metabolism<br/>Cytochrome P-450 Enzyme Inhibitors--pharmacology<br/>Drug Interactions<br/>Enzyme Induction--drug effects<br/>Gastric Acidity Determination<br/>Histone Deacetylase Inhibitors--adverse effects<br/>Humans<br/>Hydroxamic Acids--adverse effects<br/>Indoles--adverse effects<br/>Microsomes, Liver--enzymology<br/>Midazolam--pharmacokinetics<br/>Models, Biological<br/>Oxidation-Reduction<br/>Panobinostat<br/>Rifampin--pharmacokinetics