Chen, Ming-Liang <br/><br/>
Trimethylamine-N-Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3-SOD2-mtROS Signaling Pathway.  [electronic resource] 

 -  Journal of the American Heart Association  09 2017 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>2047-9980 
<br/><br/><label>Standard No.: </label>10.1161/JAHA.117.006347  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antioxidants--pharmacology<br/>Apoptosis Regulatory Proteins--metabolism<br/>Atherosclerosis--chemically induced<br/>Cells, Cultured<br/>Disease Models, Animal<br/>Dose-Response Relationship, Drug<br/>Female<br/>Genetic Predisposition to Disease<br/>Human Umbilical Vein Endothelial Cells--drug effects<br/>Humans<br/>Inflammasomes--agonists<br/>Inflammation Mediators--metabolism<br/>Methylamines--toxicity<br/>Mice, 129 Strain<br/>Mice, Knockout, ApoE<br/>Mitochondria--drug effects<br/>NLR Family, Pyrin Domain-Containing 3 Protein--agonists<br/>Phenotype<br/>RNA Interference<br/>Reactive Oxygen Species--metabolism<br/>Signal Transduction--drug effects<br/>Sirtuin 3--deficiency<br/>Superoxide Dismutase--metabolism<br/>Time Factors<br/>Transfection<br/>Vasculitis--chemically induced