TY  - GEN
AU  - Pirali,Tracey
AU  - Ciraolo,Elisa
AU  - Aprile,Silvio
AU  - Massarotti,Alberto
AU  - Berndt,Alex
AU  - Griglio,Alessia
AU  - Serafini,Marta
AU  - Mercalli,Valentina
AU  - Landoni,Clarissa
AU  - Campa,Carlo Cosimo
AU  - Margaria,Jean Piero
AU  - Silva,Rangel L
AU  - Grosa,Giorgio
AU  - Sorba,Giovanni
AU  - Williams,Roger
AU  - Hirsch,Emilio
AU  - Tron,Gian Cesare
TI  - Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs
SN  - 1860-7187
PY  - 2017///1009
KW  - Animals
KW  - Binding Sites
KW  - Carboxylic Acids
KW  - chemistry
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - drug effects
KW  - Drug Design
KW  - Enzyme Inhibitors
KW  - Humans
KW  - Hydrogen Bonding
KW  - Inhibitory Concentration 50
KW  - Mice
KW  - Microsomes
KW  - metabolism
KW  - Molecular Dynamics Simulation
KW  - Phosphatidylinositol 3-Kinases
KW  - Phosphoinositide-3 Kinase Inhibitors
KW  - Prodrugs
KW  - Protein Binding
KW  - Protein Isoforms
KW  - antagonists & inhibitors
KW  - Quinolones
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1002/cmdc.201700340
ER  -