Pirali, Tracey <br/><br/>
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.  [electronic resource] 

 -  ChemMedChem  09 2017 
 - 1542-1554 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1860-7187 
<br/><br/><label>Standard No.: </label>10.1002/cmdc.201700340  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Binding Sites<br/>Carboxylic Acids--chemistry<br/>Cell Line, Tumor<br/>Cell Proliferation--drug effects<br/>Drug Design<br/>Enzyme Inhibitors--chemistry<br/>Humans<br/>Hydrogen Bonding<br/>Inhibitory Concentration 50<br/>Mice<br/>Microsomes--metabolism<br/>Molecular Dynamics Simulation<br/>Phosphatidylinositol 3-Kinases--metabolism<br/>Phosphoinositide-3 Kinase Inhibitors<br/>Prodrugs--chemistry<br/>Protein Binding<br/>Protein Isoforms--antagonists & inhibitors<br/>Quinolones--chemistry<br/>Structure-Activity Relationship