TY - GEN AU - Rubat,Sebastián AU - Varas,Ignacio AU - Sepúlveda,Romina AU - Almonacid,Daniel AU - González-Nilo,Fernando AU - Agosin,Eduardo TI - Increasing the intracellular isoprenoid pool in Saccharomyces cerevisiae by structural fine-tuning of a bifunctional farnesyl diphosphate synthase SN - 1567-1364 PY - 2018///0515 KW - Amino Acid Motifs KW - Amino Acid Sequence KW - Amino Acid Substitution KW - Binding Sites KW - Diphosphates KW - metabolism KW - Diterpenes KW - Gene Expression Regulation, Fungal KW - Geranyltranstransferase KW - chemistry KW - Hemiterpenes KW - Kinetics KW - Metabolic Engineering KW - Molecular Docking Simulation KW - Organophosphorus Compounds KW - Point Mutation KW - Polyisoprenyl Phosphates KW - Protein Binding KW - Protein Interaction Domains and Motifs KW - Protein Structure, Secondary KW - Saccharomyces cerevisiae KW - enzymology KW - Sequence Alignment KW - Sequence Homology, Amino Acid KW - Sesquiterpenes KW - Substrate Specificity KW - Terpenes KW - Thermodynamics N1 - Publication Type: Journal Article UR - https://doi.org/10.1093/femsyr/fox032 ER -