TY  - GEN
AU  - Stepan,Antonia F
AU  - Claffey,Michelle M
AU  - Reese,Matthew R
AU  - Balan,Gayatri
AU  - Barreiro,Gabriela
AU  - Barricklow,Jason
AU  - Bohanon,Michael J
AU  - Boscoe,Brian P
AU  - Cappon,Gregg D
AU  - Chenard,Lois K
AU  - Cianfrogna,Julie
AU  - Chen,Laigao
AU  - Coffman,Karen J
AU  - Drozda,Susan E
AU  - Dunetz,Joshua R
AU  - Ghosh,Somraj
AU  - Hou,Xinjun
AU  - Houle,Christopher
AU  - Karki,Kapil
AU  - Lazzaro,John T
AU  - Mancuso,Jessica Y
AU  - Marcek,John M
AU  - Miller,Emily L
AU  - Moen,Mark A
AU  - O'Neil,Steven
AU  - Sakurada,Isao
AU  - Skaddan,Marc
AU  - Parikh,Vinod
AU  - Smith,Deborah L
AU  - Trapa,Patrick
AU  - Tuttle,Jamison B
AU  - Verhoest,Patrick R
AU  - Walker,Daniel P
AU  - Won,Annie
AU  - Wright,Ann S
AU  - Whritenour,Jessica
AU  - Zasadny,Kenneth
AU  - Zaleska,Margaret M
AU  - Zhang,Lei
AU  - Shaffer,Christopher L
TI  - Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates
SN  - 1520-4804
PY  - 2017///1016
KW  - Allosteric Regulation
KW  - drug effects
KW  - Animals
KW  - Female
KW  - HEK293 Cells
KW  - Heterocyclic Compounds, 3-Ring
KW  - adverse effects
KW  - Humans
KW  - Male
KW  - Molecular Docking Simulation
KW  - Pyridines
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Receptor, Metabotropic Glutamate 5
KW  - antagonists & inhibitors
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1021/acs.jmedchem.7b00604
ER  -