Stepan, Antonia F <br/><br/>
Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates.  [electronic resource] 

 -  Journal of medicinal chemistry  09 2017 
 - 7764-7780 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/acs.jmedchem.7b00604  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Allosteric Regulation--drug effects<br/>Animals<br/>Female<br/>HEK293 Cells<br/>Heterocyclic Compounds, 3-Ring--adverse effects<br/>Humans<br/>Male<br/>Molecular Docking Simulation<br/>Pyridines--adverse effects<br/>Rats<br/>Rats, Sprague-Dawley<br/>Receptor, Metabotropic Glutamate 5--antagonists & inhibitors<br/>Structure-Activity Relationship