TY  - GEN
AU  - Zhang,Pingzhao
AU  - Wang,Dejie
AU  - Zhao,Yu
AU  - Ren,Shancheng
AU  - Gao,Kun
AU  - Ye,Zhenqing
AU  - Wang,Shangqian
AU  - Pan,Chun-Wu
AU  - Zhu,Yasheng
AU  - Yan,Yuqian
AU  - Yang,Yinhui
AU  - Wu,Di
AU  - He,Yundong
AU  - Zhang,Jun
AU  - Lu,Daru
AU  - Liu,Xiuping
AU  - Yu,Long
AU  - Zhao,Shimin
AU  - Li,Yao
AU  - Lin,Dong
AU  - Wang,Yuzhuo
AU  - Wang,Liguo
AU  - Chen,Yu
AU  - Sun,Yinghao
AU  - Wang,Chenji
AU  - Huang,Haojie
TI  - Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation
SN  - 1546-170X
PY  - 2017///1002
KW  - Azepines
KW  - pharmacology
KW  - Blotting, Western
KW  - Cell Cycle Proteins
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - drug effects
KW  - Cell Survival
KW  - Drug Resistance, Neoplasm
KW  - Gene Expression Profiling
KW  - Humans
KW  - Immunoprecipitation
KW  - Male
KW  - Mechanistic Target of Rapamycin Complex 1
KW  - Molecular Targeted Therapy
KW  - Multiprotein Complexes
KW  - Mutation
KW  - Nuclear Proteins
KW  - antagonists & inhibitors
KW  - Prostatic Neoplasms
KW  - drug therapy
KW  - Proteasome Endopeptidase Complex
KW  - Protein Serine-Threonine Kinases
KW  - Proto-Oncogene Proteins c-akt
KW  - RNA-Binding Proteins
KW  - Repressor Proteins
KW  - genetics
KW  - Reverse Transcriptase Polymerase Chain Reaction
KW  - TOR Serine-Threonine Kinases
KW  - Transcription Factors
KW  - Triazoles
KW  - rac1 GTP-Binding Protein
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1038/nm.4379
ER  -