Zhang, Pingzhao <br/><br/>
Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.  [electronic resource] 

 -  Nature medicine  Sep 2017 
 - 1055-1062 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1546-170X 
<br/><br/><label>Standard No.: </label>10.1038/nm.4379  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Azepines--pharmacology<br/>Blotting, Western<br/>Cell Cycle Proteins<br/>Cell Line, Tumor<br/>Cell Proliferation--drug effects<br/>Cell Survival<br/>Drug Resistance, Neoplasm<br/>Gene Expression Profiling<br/>Humans<br/>Immunoprecipitation<br/>Male<br/>Mechanistic Target of Rapamycin Complex 1<br/>Molecular Targeted Therapy<br/>Multiprotein Complexes--drug effects<br/>Mutation<br/>Nuclear Proteins--antagonists & inhibitors<br/>Prostatic Neoplasms--drug therapy<br/>Proteasome Endopeptidase Complex--drug effects<br/>Protein Serine-Threonine Kinases--antagonists & inhibitors<br/>Proto-Oncogene Proteins c-akt--drug effects<br/>RNA-Binding Proteins--antagonists & inhibitors<br/>Repressor Proteins--genetics<br/>Reverse Transcriptase Polymerase Chain Reaction<br/>TOR Serine-Threonine Kinases--drug effects<br/>Transcription Factors--antagonists & inhibitors<br/>Triazoles--pharmacology<br/>rac1 GTP-Binding Protein--genetics