Janouskova, Hana <br/><br/>
Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.  [electronic resource] 

 -  Nature medicine  09 2017 
 - 1046-1054 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1546-170X 
<br/><br/><label>Standard No.: </label>10.1038/nm.4372  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Acetanilides--pharmacology<br/>Adenocarcinoma, Clear Cell--genetics<br/>Animals<br/>Apoptosis--drug effects<br/>Azepines--pharmacology<br/>Carcinoma, Endometrioid--genetics<br/>Carcinosarcoma--genetics<br/>Cell Cycle Proteins<br/>Cell Line, Tumor<br/>Cell Proliferation--drug effects<br/>Chromatography, Liquid<br/>Cullin Proteins--metabolism<br/>Drug Resistance, Neoplasm<br/>Endometrial Neoplasms--genetics<br/>Epigenesis, Genetic<br/>Female<br/>Heterocyclic Compounds, 3-Ring--pharmacology<br/>Humans<br/>Immunoblotting<br/>Immunohistochemistry<br/>Immunoprecipitation<br/>Male<br/>Mass Spectrometry<br/>Mice, Nude<br/>Molecular Targeted Therapy<br/>Mutation<br/>Neoplasm Transplantation<br/>Neoplasms, Cystic, Mucinous, and Serous--genetics<br/>Nuclear Proteins--antagonists & inhibitors<br/>Prostatic Neoplasms--genetics<br/>Protein Serine-Threonine Kinases--antagonists & inhibitors<br/>RNA-Binding Proteins--antagonists & inhibitors<br/>Repressor Proteins--genetics<br/>Reverse Transcriptase Polymerase Chain Reaction<br/>Transcription Factors--antagonists & inhibitors<br/>Triazoles--pharmacology<br/>Ubiquitination