TY  - GEN
AU  - Thomas,Charles A
AU  - Tejwani,Leon
AU  - Trujillo,Cleber A
AU  - Negraes,Priscilla D
AU  - Herai,Roberto H
AU  - Mesci,Pinar
AU  - Macia,Angela
AU  - Crow,Yanick J
AU  - Muotri,Alysson R
TI  - Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation
SN  - 1875-9777
PY  - 2018///0514
KW  - Astrocytes
KW  - drug effects
KW  - Autoimmune Diseases
KW  - enzymology
KW  - Base Sequence
KW  - Cell Extracts
KW  - Child
KW  - Cytosol
KW  - metabolism
KW  - DNA
KW  - Exodeoxyribonucleases
KW  - deficiency
KW  - Humans
KW  - Infant
KW  - Infant, Newborn
KW  - Inflammation
KW  - pathology
KW  - Interferons
KW  - pharmacology
KW  - Long Interspersed Nucleotide Elements
KW  - genetics
KW  - Male
KW  - Microcephaly
KW  - Nervous System
KW  - Neural Stem Cells
KW  - Neurons
KW  - Organoids
KW  - Phenotype
KW  - Phosphoproteins
KW  - Stem Cells
KW  - Up-Regulation
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.stem.2017.07.009
ER  -