Thomas, Charles A

Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation. [electronic resource] - Cell stem cell 09 2017 - 319-331.e8 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1875-9777

10.1016/j.stem.2017.07.009 doi


Astrocytes--drug effects
Autoimmune Diseases--enzymology
Base Sequence
Cell Extracts
Child
Cytosol--metabolism
DNA--metabolism
Exodeoxyribonucleases--deficiency
Humans
Infant
Infant, Newborn
Inflammation--pathology
Interferons--pharmacology
Long Interspersed Nucleotide Elements--genetics
Male
Microcephaly--pathology
Nervous System--pathology
Neural Stem Cells--metabolism
Neurons--drug effects
Organoids--metabolism
Phenotype
Phosphoproteins--deficiency
Stem Cells--drug effects
Up-Regulation--drug effects