The tyrosine kinase inhibitor nintedanib activates SHP-1 and induces apoptosis in triple-negative breast cancer cells. [electronic resource]
- Experimental & molecular medicine 08 2017
- e366 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2092-6413
10.1038/emm.2017.114 doi
Animals Antineoplastic Agents--pharmacology Apoptosis--drug effects Cell Line, Tumor Disease-Free Survival Female Gene Expression Regulation, Neoplastic Humans Indoles--pharmacology Kaplan-Meier Estimate Mice Mice, Inbred BALB C Protein Kinase Inhibitors--pharmacology Protein Tyrosine Phosphatase, Non-Receptor Type 6--genetics Protein-Tyrosine Kinases--metabolism RNA, Small Interfering--genetics STAT3 Transcription Factor--genetics Triple Negative Breast Neoplasms--drug therapy Xenograft Model Antitumor Assays