TY  - GEN
AU  - Kaimori,Jun-Ya
AU  - Lin,Cheng-Chao
AU  - Outeda,Patricia
AU  - Garcia-Gonzalez,Miguel A
AU  - Menezes,Luis F
AU  - Hartung,Erum A
AU  - Li,Ao
AU  - Wu,Guanqing
AU  - Fujita,Hideaki
AU  - Sato,Yasunori
AU  - Nakanuma,Yasuni
AU  - Yamamoto,Satoko
AU  - Ichimaru,Naotsugu
AU  - Takahara,Shiro
AU  - Isaka,Yoshitaka
AU  - Watnick,Terry
AU  - Onuchic,Luiz F
AU  - Guay-Woodford,Lisa M
AU  - Germino,Gregory G
TI  - NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology
SN  - 2045-2322
PY  - 2019///0225
KW  - Animals
KW  - Biomarkers
KW  - Cell Line
KW  - Disease Models, Animal
KW  - Enzyme Activation
KW  - Gene Expression
KW  - Humans
KW  - Intracellular Space
KW  - metabolism
KW  - Male
KW  - Mice
KW  - Mice, Knockout
KW  - Mice, Transgenic
KW  - Models, Biological
KW  - Mutation
KW  - Nedd4 Ubiquitin Protein Ligases
KW  - Polycystic Kidney, Autosomal Recessive
KW  - genetics
KW  - Protein Transport
KW  - Rats
KW  - Receptors, Cell Surface
KW  - deficiency
KW  - Signal Transduction
KW  - rho GTP-Binding Proteins
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/s41598-017-08284-4
ER  -