TY - GEN AU - Sebastián,María AU - Lira-Navarrete,Erandi AU - Serrano,Ana AU - Marcuello,Carlos AU - Velázquez-Campoy,Adrián AU - Lostao,Anabel AU - Hurtado-Guerrero,Ramón AU - Medina,Milagros AU - Martínez-Júlvez,Marta TI - The FAD synthetase from the human pathogen Streptococcus pneumoniae: a bifunctional enzyme exhibiting activity-dependent redox requirements SN - 2045-2322 PY - 2019///0219 KW - Bacterial Proteins KW - antagonists & inhibitors KW - Binding Sites KW - Cloning, Molecular KW - Dithionite KW - pharmacology KW - Enzyme Inhibitors KW - Escherichia coli KW - genetics KW - Flavin Mononucleotide KW - biosynthesis KW - Flavin-Adenine Dinucleotide KW - Gene Expression KW - Kinetics KW - Magnesium Chloride KW - Models, Molecular KW - Nucleotidyltransferases KW - Oxidation-Reduction KW - Phosphotransferases (Alcohol Group Acceptor) KW - Protein Binding KW - Protein Conformation, alpha-Helical KW - Protein Conformation, beta-Strand KW - Protein Interaction Domains and Motifs KW - Protein Multimerization KW - Recombinant Proteins KW - chemistry KW - Riboflavin KW - Streptococcus pneumoniae KW - drug effects KW - Substrate Specificity N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/s41598-017-07716-5 ER -