TY  - GEN
AU  - Mezeiova,Eva
AU  - Korabecny,Jan
AU  - Sepsova,Vendula
AU  - Hrabinova,Martina
AU  - Jost,Petr
AU  - Muckova,Lubica
AU  - Kucera,Tomas
AU  - Dolezal,Rafael
AU  - Misik,Jan
AU  - Spilovska,Katarina
AU  - Pham,Ngoc Lam
AU  - Pokrievkova,Lucia
AU  - Roh,Jaroslav
AU  - Jun,Daniel
AU  - Soukup,Ondrej
AU  - Kaping,Daniel
AU  - Kuca,Kamil
TI  - Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy
SN  - 1420-3049
PY  - 2018///0423
KW  - Acetylcholinesterase
KW  - Alzheimer Disease
KW  - drug therapy
KW  - Aminoquinolines
KW  - chemical synthesis
KW  - Binding Sites
KW  - Blood-Brain Barrier
KW  - metabolism
KW  - Butyrylcholinesterase
KW  - Catalytic Domain
KW  - Cell Line, Tumor
KW  - Cell Survival
KW  - drug effects
KW  - Cholinesterase Inhibitors
KW  - chemistry
KW  - Drug Design
KW  - Drug Discovery
KW  - Enzyme Activation
KW  - Heterocyclic Compounds, 4 or More Rings
KW  - Humans
KW  - Hydrolysis
KW  - Inhibitory Concentration 50
KW  - Models, Molecular
KW  - Molecular Conformation
KW  - Molecular Structure
KW  - Permeability
KW  - Protein Binding
KW  - Structure-Activity Relationship
KW  - Tacrine
KW  - analogs & derivatives
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.3390/molecules22081265
ER  -