TY  - GEN
AU  - Yi,Bitna
AU  - Jahangir,Alam
AU  - Evans,Andrew K
AU  - Briggs,Denise
AU  - Ravina,Kristine
AU  - Ernest,Jacqueline
AU  - Farimani,Amir B
AU  - Sun,Wenchao
AU  - Rajadas,Jayakumar
AU  - Green,Michael
AU  - Feinberg,Evan N
AU  - Pande,Vijay S
AU  - Shamloo,Mehrdad
TI  - Discovery of novel brain permeable and G protein-biased beta-1 adrenergic receptor partial agonists for the treatment of neurocognitive disorders
SN  - 1932-6203
PY  - 2017///1023
KW  - Adrenergic beta-1 Receptor Agonists
KW  - chemistry
KW  - Alzheimer Disease
KW  - drug therapy
KW  - Animals
KW  - Brain
KW  - metabolism
KW  - CHO Cells
KW  - Cell Line, Tumor
KW  - Cells, Cultured
KW  - Cricetinae
KW  - Cricetulus
KW  - Crystallography, X-Ray
KW  - Drug Discovery
KW  - GTP-Binding Proteins
KW  - Humans
KW  - Magnetic Resonance Spectroscopy
KW  - Male
KW  - Mice, Inbred C57BL
KW  - Models, Chemical
KW  - Models, Molecular
KW  - Molecular Structure
KW  - Neurocognitive Disorders
KW  - Permeability
KW  - Phenyl Ethers
KW  - Propanolamines
KW  - Protein Binding
KW  - Rats, Sprague-Dawley
KW  - Receptors, Adrenergic, beta-1
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1371/journal.pone.0180319
ER  -