Granulocyte colony-stimulating factor (GCSF) fused with Fc Domain produced from E. coli is less effective than Polyethylene Glycol-conjugated GCSF. [electronic resource]
- Scientific reports 07 2017
- 6480 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2045-2322
10.1038/s41598-017-06726-7 doi
Animals Cell Line Cell Proliferation--drug effects Escherichia coli--genetics Granulocyte Colony-Stimulating Factor--genetics Humans Hydrogen-Ion Concentration Immunoglobulin Fc Fragments--genetics Neutropenia--drug therapy Polyethylene Glycols--chemistry Protein Engineering--methods Rats, Sprague-Dawley Recombinant Proteins--genetics