TY  - GEN
AU  - Hiruma,Yoshitaka
AU  - Koch,Andre
AU  - Hazraty,Nazila
AU  - Tsakou,Foteini
AU  - Medema,René H
AU  - Joosten,Robbie P
AU  - Perrakis,Anastassis
TI  - Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures
SN  - 1083-351X
PY  - 2017///0926
KW  - Adenosine Triphosphate
KW  - chemistry
KW  - Amino Acid Substitution
KW  - Antineoplastic Agents
KW  - Binding Sites
KW  - Catalytic Domain
KW  - Cell Cycle Proteins
KW  - antagonists & inhibitors
KW  - Crystallography, X-Ray
KW  - Humans
KW  - Kinetics
KW  - Ligands
KW  - Models, Molecular
KW  - Molecular Structure
KW  - Morpholines
KW  - Phosphorylation
KW  - drug effects
KW  - Point Mutation
KW  - Protein Kinase Inhibitors
KW  - Protein Processing, Post-Translational
KW  - Protein Serine-Threonine Kinases
KW  - Protein-Tyrosine Kinases
KW  - Purines
KW  - Pyrazoles
KW  - Quinazolines
KW  - Recombinant Fusion Proteins
KW  - Recombinant Proteins
N1  - Publication Type: Comparative Study; Journal Article
UR  - https://doi.org/10.1074/jbc.M117.783555
ER  -