TY - GEN AU - Yap,Yoon-Sim AU - Kwok,Li-Lian AU - Syn,Nicholas AU - Chay,Wen Yee AU - Chia,John Whay Kuang AU - Tham,Chee Kian AU - Wong,Nan Soon AU - Lo,Soo Kien AU - Dent,Rebecca Alexandra AU - Tan,Sili AU - Mok,Zuan Yu AU - Koh,King Xin AU - Toh,Han Chong AU - Koo,Wen Hsin AU - Loh,Marie AU - Ng,Raymond Chee Hui AU - Choo,Su Pin AU - Soong,Richie Chuan Teck TI - Predictors of Hand-Foot Syndrome and Pyridoxine for Prevention of Capecitabine-Induced Hand-Foot Syndrome: A Randomized Clinical Trial SN - 2374-2445 PY - 2017///1128 KW - Adult KW - Aged KW - Aged, 80 and over KW - Antimetabolites, Antineoplastic KW - adverse effects KW - Asian People KW - genetics KW - Capecitabine KW - Chi-Square Distribution KW - Dihydrouracil Dehydrogenase (NADP) KW - Double-Blind Method KW - Drug Administration Schedule KW - Female KW - Folic Acid KW - blood KW - Genetic Predisposition to Disease KW - Genome-Wide Association Study KW - Hand-Foot Syndrome KW - Humans KW - Incidence KW - Intracellular Signaling Peptides and Proteins KW - Kaplan-Meier Estimate KW - Logistic Models KW - Male KW - Membrane Proteins KW - Microfilament Proteins KW - Middle Aged KW - Multivariate Analysis KW - Neoplasms KW - Odds Ratio KW - Pharmacogenomic Variants KW - Polymorphism, Single Nucleotide KW - Predictive Value of Tests KW - Pyridoxine KW - administration & dosage KW - Risk Assessment KW - Risk Factors KW - Severity of Illness Index KW - Singapore KW - epidemiology KW - Time Factors KW - Treatment Outcome N1 - Publication Type: Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial UR - https://doi.org/10.1001/jamaoncol.2017.1269 ER -