Wang, Yu-Qing <br/><br/>
Design, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c-MYC Transcription Inhibitors via Disruption of the NM23-H2/G-Quadruplex Interaction.  [electronic resource] 

 -  Journal of medicinal chemistry  08 2017 
 - 6924-6941 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/acs.jmedchem.7b00421  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antineoplastic Agents--administration & dosage<br/>Apoptosis--drug effects<br/>Cell Line, Tumor<br/>Cell Proliferation--drug effects<br/>Down-Regulation<br/>Doxorubicin--pharmacology<br/>Drug Design<br/>G-Quadruplexes<br/>G1 Phase Cell Cycle Checkpoints--drug effects<br/>Humans<br/>Ligands<br/>Mice, Inbred BALB C<br/>Molecular Docking Simulation<br/>NM23 Nucleoside Diphosphate Kinases--antagonists & inhibitors<br/>Promoter Regions, Genetic<br/>Proto-Oncogene Proteins c-myc--antagonists & inhibitors<br/>Pyrroles--administration & dosage<br/>Quinazolines--administration & dosage<br/>Quinazolinones--administration & dosage<br/>Structure-Activity Relationship<br/>Transcription, Genetic<br/>Xenograft Model Antitumor Assays