TY  - GEN
AU  - Corte,James R
AU  - Yang,Wu
AU  - Fang,Tianan
AU  - Wang,Yufeng
AU  - Osuna,Honey
AU  - Lai,Amy
AU  - Ewing,William R
AU  - Rossi,Karen A
AU  - Myers,Joseph E
AU  - Sheriff,Steven
AU  - Lou,Zhen
AU  - Zheng,Joanna J
AU  - Harper,Timothy W
AU  - Bozarth,Jeffrey M
AU  - Wu,Yiming
AU  - Luettgen,Joseph M
AU  - Seiffert,Dietmar A
AU  - Quan,Mimi L
AU  - Wexler,Ruth R
AU  - Lam,Patrick Y S
TI  - Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency
SN  - 1464-3405
PY  - 2017///0830
KW  - Amides
KW  - chemical synthesis
KW  - Crystallography, X-Ray
KW  - Dose-Response Relationship, Drug
KW  - Drug Discovery
KW  - Factor XIa
KW  - antagonists & inhibitors
KW  - Humans
KW  - Macrocyclic Compounds
KW  - Models, Molecular
KW  - Molecular Structure
KW  - Serine Proteinase Inhibitors
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1016/j.bmcl.2017.06.058
ER  -