TY  - GEN
AU  - Ellermann,Manuel
AU  - Eheim,Ashley
AU  - Rahm,Fredrik
AU  - Viklund,Jenny
AU  - Guenther,Judith
AU  - Andersson,Martin
AU  - Ericsson,Ulrika
AU  - Forsblom,Rickard
AU  - Ginman,Tobias
AU  - Lindström,Johan
AU  - Silvander,Camilla
AU  - Trésaugues,Lionel
AU  - Giese,Anja
AU  - Bunse,Stefanie
AU  - Neuhaus,Roland
AU  - Weiske,Jörg
AU  - Quanz,Maria
AU  - Glasauer,Andrea
AU  - Nowak-Reppel,Katrin
AU  - Bader,Benjamin
AU  - Irlbacher,Horst
AU  - Meyer,Hanna
AU  - Queisser,Nina
AU  - Bauser,Marcus
AU  - Haegebarth,Andrea
AU  - Gorjánácz,Mátyás
TI  - Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target
SN  - 1554-8937
PY  - 2018///0220
KW  - Animals
KW  - Antineoplastic Agents
KW  - chemistry
KW  - Caco-2 Cells
KW  - Cells, Cultured
KW  - DNA Repair Enzymes
KW  - antagonists & inhibitors
KW  - Drug Delivery Systems
KW  - Enzyme Activation
KW  - drug effects
KW  - HeLa Cells
KW  - Hepatocytes
KW  - Humans
KW  - MCF-7 Cells
KW  - Mice
KW  - Mice, Nude
KW  - Microsomes, Liver
KW  - Models, Molecular
KW  - Morpholines
KW  - Neoplasms
KW  - drug therapy
KW  - Phosphoric Monoester Hydrolases
KW  - Pyrimidines
KW  - Rats
N1  - Publication Type: Research Support, Non-U.S. Gov't; Journal Article
UR  - https://doi.org/10.1021/acschembio.7b00370
ER  -