Ellermann, Manuel <br/><br/>
Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.  [electronic resource] 

 -  ACS chemical biology  08 2017 
 - 1986-1992 p.  digital 
<br/><br/> Publication Type: Research Support, Non-U.S. Gov't; Journal Article 
<br/><br/><label>ISSN: </label>1554-8937 
<br/><br/><label>Standard No.: </label>10.1021/acschembio.7b00370  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antineoplastic Agents--chemistry<br/>Caco-2 Cells<br/>Cells, Cultured<br/>DNA Repair Enzymes--antagonists & inhibitors<br/>Drug Delivery Systems<br/>Enzyme Activation--drug effects<br/>HeLa Cells<br/>Hepatocytes--drug effects<br/>Humans<br/>MCF-7 Cells<br/>Mice<br/>Mice, Nude<br/>Microsomes, Liver--drug effects<br/>Models, Molecular<br/>Morpholines--chemistry<br/>Neoplasms--drug therapy<br/>Phosphoric Monoester Hydrolases--antagonists & inhibitors<br/>Pyrimidines--chemistry<br/>Rats