Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function. [electronic resource]
- Nature communications 07 2017
- 16050 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2041-1723
10.1038/ncomms16050 doi
ATPases Associated with Diverse Cellular Activities--metabolism Animals Blood-Brain Barrier--metabolism Endocytosis Endosomal Sorting Complexes Required for Transport--metabolism Endosomes--metabolism Endothelial Cells--metabolism Eye Diseases, Hereditary--genetics Eye Proteins--genetics Familial Exudative Vitreoretinopathies Frizzled Receptors--genetics HEK293 Cells HeLa Cells Humans In Vitro Techniques Lysosomes--metabolism Mice Multivesicular Bodies--metabolism Mutation Neovascularization, Physiologic Nerve Tissue Proteins--genetics Protein Transport Retina Retinal Diseases--genetics Retinal Vessels--growth & development Ubiquitination Vacuolar Proton-Translocating ATPases--metabolism Wnt Signaling Pathway